Hard gelatin capsules orange to brown in colour, containing 5mg pimobendan per capsule. For the treatment of canine congestive heart failure originating from dilated cardiomyopathy or valvular insufficiency (mitral and/or tricuspid regurgitation). When used in cases of valvular insufficiency in conjunction with frusemide the product has been shown to improve the quality of life and extend life expectancy in treated dogs. When used in a limited number of cases of dilated cardiomyopathy in conjunction with frusemide, enalapril and digoxin, the product has been shown to improve the quality of life and to extend life expectancy in treated dogs.Dosage and administration
See dosing table below.Vetmedin 1.25mg, 2.5mg and 5mg Capsules Dosage Guide Body weight Daily Dosage Morning Evening(kg)(mg)1.25mg 2.5mg 5.0mg 1.25mg 2.5mg 5.0mg Vetmedin capsules should be administered orally (approximately one hour before feeding) at a dose of 0.2mg to 0.6mg pimobendan/kg body weight per day. The daily dose should be divided into two equal administrations, one half of the dose given in the morning and the other half approximately 12 hours later. Determine the bodyweight accurately before prescribing to ensure administration of the correct dosage.In cases of mild congestive heart failure, a daily dosage at the lower end of the dose range may be adequate. If, however, a clear response is not observable within one week, the dosage should be raised.Vetmedin capsules may be combined with a diuretic treatment such as frusemide.Contra-indications, warnings, etc.
Vetmedin capsules should not be used in cases of hypertrophic cardiomyopathies or clinical conditions where an augmentation of cardiac output is not possible for functional or anatomical reasons (e.g. aortic stenosis). The product should only be used in dogs with cardiac insufficiency.A moderate positive chronotropic effect and vomiting may occur in rare cases. However, these cases are dose-dependent and may be avoided by reducing the dose.In studies with rats and rabbits, pimobendan had no effect on fertility and embryotoxic effects occurred only at maternotoxic doses. In experiments with rats it has been shown that pimobendan is excreted into milk. No information is available on the safety of Vetmedin in pregnant and lactating bitches.The pimobendan-induced increase in contractility of the heart is attenuated in the presence of the calcium antagonist verapamil and the ß-antagonist propranolol. In pharmacological studies no interaction between the cardiac glycoside ouabain and pimobendan was detected.In the case of overdose, symptomatic treatment should be initiated.Dispose of used packaging in the household refuse. Unused product should be returned to the Veterinary Surgeon.
Pimobendan, a benzimidazole-pyridazinone derivative, is a non-sympathomimetic, non-glycoside inotropic substance with potent vasodilatative properties. It increases calcium sensitivity of cardiac myofilaments and inhibits phosphodiesterase (type III). It also exhibits a vasodilatory action through inhibition of phosphodiesterase III activity.As the bioavailability of pimobendan is considerably reduced when administered with or shortly after food, it is recommended that animals are treated approximately 1 hour before feeding.