|
PRESCRIPTION REQUIRED: Click Here for more information.
Fortekor can be dispensed in packets of 28 tablets
or 56 tablets.
FORTEKOR Flavoured Tablets 5mg are indicated
for the treatment of heart failure in dogs and chronic renal insufficiency in
cats. The active ingredient is benazepril.
After oral administration, benazepril is rapidly
absorbed from the gastrointestinal tract and hydrolysed into benazeprilat, a
highly specific and potent inhibitor of angiotensin converting enzyme (ACE).
FORTEKOR Flavoured Tablets 5mg produces
significant inhibition of plasma ACE activity for more than 24 hours after a
single dose in cats and dogs. Inhibition of ACE leads to reduced conversion of
inactive angiotensin I into angiotensin II and therefore reduction in the
effects mediated by angiotensin II, including vasoconstriction of both arteries
and veins, retention of sodium and water by the kidney and remodelling effects
(including pathological cardiac hypertrophy and degenerative renal
changes).
In dogs with heart failure, FORTEKOR
Flavoured Tablets 5mg lowers the blood pressure and volume loading on the heart.
FORTEKOR Flavoured Tablets 5mg leads to a significant extension of the life span
of dogs with heart failure and also improves clinical signs, notably reduction
in coughing and improvement of the quality of life.
In contrast with other ACE inhibitors,
benazeprilat is excreted equally by both biliary and urinary routes in dogs and
primarily via the biliary route in cats and therefore no adjustment of the dose
of FORTEKOR Flavoured Tablets 5mg is necessary in the treatment of cats with
renal insufficiency.
In cats with chronic renal insufficiency,
Fortekor reduces the protein loss in urine and lowers the systemic and
intraglomerular blood pressure. Reduction in glomerular hypertension retards the
progression of kidney disease by inhibition of further damage to the kidneys.
Fortekor increases the appetite, quality of life and the survival time of the
cats, particularly in advanced disease.
 |
