Nelio Flavoured Tablets Cats
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Flavoured, clover shaped scored beige tablet, divisible into halves or quarters. Each tablet contains benazepril (as hydrochloride) 4.60mg (equivalent to benazepril hydrochloride 5mg)
Dosage and administration:
- Oral administration of 0.46mg of benazepril per kg and per day, equivalent to 0.50mg of benazepril hydrochloride per kg and per day, as one administration, whether or not with a meal.
- The tablets are flavoured and may be taken spontaneously by cats, but can also be administered directly into the cat's mouth or be given with food if necessary.
- Benazepril may cause mild, intermittent diarrhea in a small proportion of cats.
- In cats with chronic renal insufficiency, benazepril may increase plasma creatinine concentrations at the start of therapy. This effect is related to the therapeutic effect of the product in reducing blood pressure, and therefore is not necessarily a reason to stop therapy in the absence of other signs.
- Benazepril reduced erythrocyte counts in normal cats at high doses, but this effect was not observed at the recommended dose during clinical trials in cats with chronic renal insufficiency. As is routine in cases of chronic renal insufficiency, it is recommended to monitor erythrocyte counts during therapy.
- Emesis, anorexia, dehydration and lethargy have been reported in rare occasions in cats.
- Laboratory studies in rats have shown embryotoxic effects of Benazepril at non-maternotoxic doses (urinary system abnormalities in foetus). Benazepril administered to cats at a daily dose of 10 mg / kg for 52 weeks resulted in the reduction of ovary / oviduct weights. Safety of this product has not been tested in pregnant or lactating queens. Do not use in pregnant or lactating females or in queens intended for breeding.
- Blood pressure may be monitored during anesthesia in cats receiving benazepril.
- Interactions with potassium preserving diuretics like spironolactone, triamterene or amiloride cannot be ruled out. It is recommended to monitor plasma potassium levels when using benazepril in combination with a potassium sparing diuretic as life threatening reactions are a possibility.
- Transient and reversible signs of hypotension may appear in case of accidental overdose. Treatment is symptomatic, involving intravenous infusion with warm isotonic saline.
- No evidence of renal toxicity to benazepril has been observed in cats during clinical trials. However, as is routine in cases of renal insufficiency, it is recommended to monitor plasma urea and creatinine levels.
- Efficacy and safety of benazepril have not been established in cats of weight less than 2.5kg.
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